Rpn13-Pru domain, human recombinant

Code No: CY-R2072
Datasheet: 
Background: 

The novel proteasome subunit Rpn13 binds to Lys48-linked diubiquitin with high affinity through a novel ubiquitin-binding domain (pleckstrin-like receptor for ubiquitin: Pru) and to ubiquitin-like (UBL) domains of UBL-ubiquitin-associated (UBA) proteins as well as to de-ubiquitinating enzyme Uch37/UCHL5.

Size: 
100 ?g
Product Type: 
Reagent
Species Reactivities: 
Human
Storage Temp. (°C): 
-70
Shipping Temp. (°C): 
Dry Ice
References: 

1. Husnjak, K. et al. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 453, 481-488, 2008
2. Schreiner, P. et al. Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature 453, 548-552, 2008
3. Hicke, L., Schubert, H. L. & Hill, C. P. Ubiquitin-binding domains. Nature Rev. Mol. Cell Biol. 6, 610-621, 2005

Reactivity: 
H
Intended Use: 
For Research use only. Not for use in diagnostic procedure.