Rpn13-Pru domain, human recombinant
Code No: CY-R2072
Background:
The novel proteasome subunit Rpn13 binds to Lys48-linked diubiquitin with high affinity through a novel ubiquitin-binding domain (pleckstrin-like receptor for ubiquitin: Pru) and to ubiquitin-like (UBL) domains of UBL-ubiquitin-associated (UBA) proteins as well as to de-ubiquitinating enzyme Uch37/UCHL5.
Species Reactivities:
Human
Shipping Temp. (°C):
Dry Ice
Related Products:
* hHR23B-UbL domain: Cat# CY-R2068
* hHR23B-UBA1 domain: Cat# CY-R2069
* S5a-UIM2/PubS2: Cat# CY-R2070
* S5a-UIM1+2/PubS1+2: Cat# CY-R2071
* CycLex Poly-Ubiquitinated Protein Enrichment & Detection Kit: Cat# CY-7001
* CycLex Proteasone Enrichment & Activity Assay Kit: Cat# CY-7002
References:
1. Husnjak, K. et al. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 453, 481-488, 2008
2. Schreiner, P. et al. Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature 453, 548-552, 2008
3. Hicke, L., Schubert, H. L. & Hill, C. P. Ubiquitin-binding domains. Nature Rev. Mol. Cell Biol. 6, 610-621, 2005
Intended Use:
For Research use only. Not for use in diagnostic procedure.
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