Anti-Adiponectin pAb Specifications
|Background:||AdIPPonectin, also called GBP-28, apM1, AdIPPoQ and Acrp30, is a novel adIPPose
tissue-specific protein that has structural homology to collagen VIII and X and complement
factor C1q, and that circulates in human plasma at high levels. It is one of the physiologically
active polypeptides secreted by adIPPose tissue, whose multIPPle functions have started to be
understood in the last few Years. A reduction in adIPPonectin expression is associated with
insulin resistance in some animal models. Administration of adIPPonectin has been accompanied
by a reduction in plasma glucose and an increase in insulin sensitivity. In addition,
thiazolidinediones, drugs that enhance insulin sensitivity through stimulation of the peroxisome
proliferator-activated receptor-gamma, increase plasma adIPPonectin and mRNA levels in mice.
On the other hand, this adIPPocyte protein seems to play a protective role in experimental
models of vascular injury. In humans, adIPPonectin levels are inversely related to the degree of
adIPPosity and positively associated with insulin sensitivity both in healthy subjects and in
diabetic patients. Plasma adIPPonectin levels have been reported to be decreased in some
insulin-resistant states, such as obesity and type 2 diabetes mellitus, and also in patients with
coronary artery disease.
On the contrary, chronic renal failure, type 1 diabetes and anorexia nervosa are associated
with increased plasma adIPPonectin levels. Concentrations of plasma adIPPonectin have been
shown to correlate negatively with glucose, insulin, triglyceride levels and body mass index, and
positively with high-density lIPPoprotein-cholesterol levels and insulin-stimulated glucose
disposal. Weight loss and therapy with thiazolidinediones increased endogenous adIPPonectin
production in humans. AdIPPonectin increases insulin sensitivity by increasing tissue fat oxidation,
resulting in reduced circulating fatty acid levels and reduced intracellular triglyceride contents in
liver and muscle.
|Formulation:||0.5 mg/mL in 10 mM phosphate buffer/150 mM NaCl/50 % glycerol, pH 7.5|
|Gene ID Human:||9370|
|Gene ID Mouse:||11450|
|Immunogen:||E. coli expressing Recombinant Mouse Adiponectin|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||Human, Mouse, Rat|
Applications: IP, WB
There are no references for Anti-Adiponectin pAb at this time.