Angiogenesis
Apoptosis
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Cancer & Cell Proliferation
Cell Surface Antigens
Cellular Stress
Cytokines & Growth Factors
Epigenetics
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Inflammation & Immunology
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Product Catalog |
anti-S100A10Code No: CY-M1036
Target:
S100A10 Background:
S100A10, a member of the S100 family of Ca2+-binding proteins, is a dimeric protein composed of two 11-kDa subunits. The protein is cytosolic when present as a dimer. Typically, S100A10 is found in most cells bound to annexin A2 as the heterotetrameric (S100A10)2-(annexin A2)2 complex, AIIt, in a calcium-independent manner (1). The formation of AIIt results in the translocation of S100A10 to the plasma membrane (2-4). S100A10 has been shown to regulate plasma membrane ion channels (5, 6) as well as cytosolic phospholipase A2 (7). In addition to an intracellular distribution, it has also been established that the heterotetrameric form of S100A10 is present on the extracellular surface of many cells (8–14). Extracellularly, the S100A10 subunit functions as a plasminogen receptor (15, 16). The penultimate and ultimate carboxyl-terminal lysines of this subunit bind tPA and plasminogen (17) and regulate the stimulation of tPA-dependent plasminogen activation (18).
Size:
100 μg
Application:
ELISA
Application:
WB
Clone Number:
YK-1B12
Product Type:
Primary Antibody
Host Species:
Mouse
Species Reactivities:
Human
Isotype:
IgG1
Storage Temp. (°C):
4
Shipping Temp. (°C):
-20 Pictures:
 References:
1. Donato, R. (2001) Int. J. Biochem. Cell Biol. 33, 637–668 2. Gerke, V., and Moss, S. E. (2002) Physiol. Rev. 82, 331–371 3. Donato, R., and Russo-Marie, F. (1999) Cell Calcium 26, 85–89 4. Seaton, B. A., and Dedman, J. R. (1998) Biometals 11, 399–404 5. Girard, C. et al. (2002) EMBO J. 21, 4439–4448 6. Okuse, K. et al. (2002) Nature 417, 653–656 7. Wu, T. et al. (1997) J. Biol. Chem. 272, 17145–17153 8. Yeatman, T. J. et al. (1993) Clin. Exp. Metastasis 11, 37–44 9. Tressler, R. J. et al. (1993) J. Cell. Biochem. 53, 265–276 10. Balch, C., and Dedman, J. R. (1997) Exp. Cell Res. 237, 259–263 11. Siever, D. A., and Erickson, H. P. (1997) Int. J. Biochem. Cell Biol. 29, 1219–1223 12. Falcone, D. J. et al. (2001) Blood 97, 777–784 13. Kassam, G. et al. (1998) J. Biol. Chem. 273, 4790–4799 14. Mai, J. et al. (2000) J. Biol. Chem. 275, 12806–12812 15. Kassam, G. et al. (1998) Biochemistry 37, 16958–16966 16. Choi, K. S. et al. (2003) FASEB J. 17, 235–246 17. MacLeod, T. J. et al. (2003) J. Biol. Chem. 278, 25577–25584 18. Fogg, D. K et al. (2002) Biochemistry 41, 4953–4961 Reactivity:
H
Intended Use:
For Research use only. Not for use in diagnostic procedure. |
