Solutions for Life Science & Diagnostics
Anti-NAMPT mAb
Additional Information
Anti-NAMPT mAb Specifications
| Background: | Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B-cell colony-enhancing factor, is the rate-limiting enzyme that converts nicotinamide to nicotinamide mononucleotide (NMN) from nicotinamide in the salvage pathway of NAD+ biosynthesis in mammals. Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) converts NMN to NAD+. The expression of NAMPT is upregulated during activation of immune cells such as monocytes, macrophages, dendritic cells, T and B cells, as well as in amniotic epithelial cells upon stimulation with several inflammatory cytokines. NAMPT-specific inhibitor, FK866 was found to deplete intracellular NAD content, resulting in apoptotic cell death in many cancer cell lines without any DNA damaging effect. Recently, Nakahata K et al, demonstrated that NAMPT is required to modulate circadian gene expression and circadian oscillation of NAD+ |
| Clonality: | Monoclonal |
| Clone Number: | AF-1E12 |
| Formulation: | 1.0 mg/mL in 20 mM phosphate buffer/300 mM NaCl/50 % glycerol, pH 7.5 |
| Gene ID Human: | 10135 |
| Gene ID Mouse: | 59027 |
| Host Species: | Mouse |
| Immunogen: | His-tagged human NAMPT |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2a |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 µg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | NAMPT |
Applications: ELISA, IP
| ELISA: | Optimal Dilution to be determined by end user. |
| IPP: | 1-2 μg/sample |
There are no references for Anti-NAMPT mAb at this time.
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