- Diagnostic Products
- Research Products
|Background:||PTPN6/SHP-1 is expressed at high levels in hematopoietic cells of all lineages and its expression is induced early in hematopoietic differentiation. Insulin stimulates the phosphorylation and activation of PTPN6/SHP-1 by a direct association between PTPN6/SHP-1 and the insulin receptor. PTPN6/SHP-1 plays a crucial role in negatively modulating insulin action and clearance in the liver, thereby regulating whole-body glucose homeostasis. PTPN6/SHP-1 is also reported as a negative regulator in the development of allergic responses such as allergic asthma.|
|Gene ID Human:||5777|
|Gene ID Mouse:||15170|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
There are no references for Protein Tyrosine Phosphatase PTPN6/SHP-1 (Human, Active) at this time.