Protein Tyrosine Phosphatase PTPRA 1st Catalytic Domain (human recombinant)

Datasheet:

Target:

PTPRA

Background:

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Receptor-type tyrosine-protein phosphatase alpha (PTPRA) contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein tyrosine phosphatase (PTPase) domains. PTPRA has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. PTPRA has been also shown to interact with Grb2 and KCNA2.

Size:

50 μg

Product Type:

Protein

Species Reactivities:

Human

Storage Temp. (°C):

-70

Shipping Temp. (°C):

Dry Ice

References:

Jirik FR, Janzen NM, Melhado IG, Harder KW. "Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase". FEBS Lett 273 (1-2): 239–42, 1990.
2. Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J. "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proc Natl Acad Sci U S A 87 (18): 7000–4, 1990.
3. den Hertog, J, Hunter T. "Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains". EMBO J. 15 (12): 3016–27. 1996.
4. den Hertog, J, Tracy S, Hunter T. "Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo". EMBO J. 13 (13): 3020–32. 1994.
5. Zheng, Xin-Min, Resnick Ross J, Shalloway David. "Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation". J. Biol. Chem. 277 (24): 21922–9. 2002.

Formulation:

The recombinant protein is supplied frozen in a buffer containing 100mM NaCl, 20mM Tris-HCl (pH 7.0), 1mM DTT, 1mM EDTA and 50% glycerol. Use a same buffer for dilution when needed.

Intended Use:

For Research use only. Not for use in diagnostic procedure.

Product Catalog

Protein Tyrosine Phosphatase PTPRA 1st Catalytic Domain (human recombinant)

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