- Diagnostic Products
- Research Products
|Alternative Names:||nicotinamide phosphoribosyltransferase|
|Background:||Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B-cell colony-enhancing factor, is the rate-limiting enzyme that converts nicotinamide to nicotinamide mononucleotide (NMN) from nicotinamide in the salvage pathway of NAD biosynthesis in mammals. Nicotinamide mononucleotide adenylyltransferase 1 converts NMN to NAD. The expression of NAMPT is upregulated during activation of immune cells such as monocytes, macrophages, dendritic cells, T and B cells, as well as in amniotic epithelial cells upon stimulation with several inflammatory cytokines. NAMPT-specific inhibitor, FK866 was found to deplete intracellular NAD content, resulting in apoptotic cell death in many cancer cell lines without any DNA damaging effect.|
|Gene ID Human:||10135|
|Gene ID Mouse:||59027|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
There are no references for NAMPT(Human, Active) at this time.