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|Background:||14-3-3 proteins are a family of conserved regulatory molecules expressed in all eukaryotic cells. There are seven genes, Î², Î³, Îµ, Ïƒ, Î¶, Ï„ and Î·, that encode 14-3-3s in most mammals. 14-3-3 proteins have the ability to bind phospho-Ser/Thrmotifs, as well as phosphorylation-independent interactions, on a multitude of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors. The family dynamically regulates the activity of target proteins in various signaling pathways that control diverse physiological and pathological processes. More than 100 signaling proteins have been reported as 14-3-3 proteinsâ€™ targets. Either an abnormal state of 14-3-3 protein expression or dysregulation of 14-3-3/terget protein interactions contributes to the development of many human diseases. Clinical investigations have demonstrated a correlation between up-regulated 14-3-3 protein levels and poor survival of cancer patients. Several studies have also suggested that 14-3-3 isoforms are differentially regulated in cancer and neurological syndromes. Especially, elevated amounts of the gamma isoform (14-3-3 Gamma) are found in the cerebrospinal fluid (CSF) of Creutzfeldt-Jakob disease (CJD) patients and could be as a specific marker of the disease as well as tau protein level.|
|Gene ID Human:||7532|
|Gene ID Mouse:||22628|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||ELISA Kit|
There are no references for CircuLex 14-3-3 Gamma ELISA Kit at this time.