Solutions for Life Science & Diagnostics
CircuLex Human soluble LOX-1/OLR1 ELISA Kit
This Kit is used for the quantitative measurement of human soluble LOX-1 in cell extract, cell conditioned medium and other biological samplesAdditional Information
CircuLex Human soluble LOX-1/OLR1 ELISA Kit Specifications
| Background: | Lectin-like oxidized LDL receptor-1 (LOX-1), a 52-kD type II transmembrane receptor for oxidized low-density lipoproteins (ox-LDL) belonging to the C-type lectin family is present primarily on endothelial cells (1). Accumulating evidences indicate that oxLDL uptake through this receptor induces endothelial dysfunction. oxLDL binding to endothelial LOX-1 generates superoxide anions, decreases nitric oxide production, and activates NF-kB (2, 3). Endothelial LOX-1 expression is induced by various pro-inflammatory cytokines, such as TNF-alpha (4) and TGF-beta (5) as well as by pro-atherogenic factors, such as oxLDL and advanced glycation end products in vitro (6). This receptor is expressed in the aortas of hypertensive, diabetic, and hyperlipidemic animals (6-8) and is upregulated in early human atherosclerotic lesions (9). These results suggest that LOX-1 may be expressed locally and play important roles in atherogenesis by internalizing and degrading oxLDL and in inflammatory responses in vivo. LOX-1 can be cleaved from the cell surface and released as soluble LOX-1 (sLOX-1), and elevated sLOX-1 levels may be indicative of atherosclerotic plaque instability (10). |
| Gene ID Human: | 4973 |
| Gene ID Mouse: | 108078 |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Product Type: | ELISA Kit |
| Shipping: | 4 |
| Size: | 96 assays |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | 4℃ |
| Target: | sLOX-1/OLR1 |
Applications: ELISA
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