Solutions for Life Science & Diagnostics
CircuLex Human AIM/CD5L/Spα ELISA kit
This Kit is used for the quantitative measurement of free form human AIM/CD5L/Sp in serum, plasma and other biological media.Additional Information
CircuLex Human AIM/CD5L/Spα ELISA kit Specifications
| Background: | CD5L, also called Spα/AIM, is a soluble 38 or 40-kDa glycoprotein expressed by macrophages present in lymphoid tissues (spleen, lymph node, thymus, and bone marrow), for which little functional and structural information is available (1). It belongs to the group B of the scavenger receptor cysteine-rich (SRCR) superfamily that includes the lymphocyte surface receptors CD5 and CD6 among others. CD5L is able to bind to not only myelomonocytic and lymphoid cells (2), but also the surface of several Gram-positive and Gram-negative bacterial strains (3), which suggests that it may play an important role in the regulation of the innate and adaptive immune systems. It has been reported that CD5L is present in IgM fraction, but not IgG or IgA fractions, from human serum (4). CD5L is a circulating protein that may play a role in the homeostasis of IgM antibodies. In addition, it has been reported that the murine homolog of CD5L, AIM, expression was induced in mouse macrophages in response to loading with highly oxidized low density lipoprotein (5), and that AIM was expressed in foam cells within atherosclerotic lesions. CD5L may be feasible as a potential biomarker in the diagnosis and treatment of atopic dermatitis (6), although CD5L was reported as candidate marker in asthma (7) and liver cirrhosis (8, 9) |
| Gene ID Human: | 922 |
| Gene ID Mouse: | 11801 |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Product Type: | ELISA Kit |
| Shipping: | 4 |
| Size: | 96 assays |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | 4℃ |
| Target: | CD5L |
Applications: ELISA
There are no references for CircuLex Human AIM/CD5L/Spα ELISA kit at this time.
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