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|Background:||AIM, also called CD5L/SPÎ±, is a soluble 38 or 40-kDa glycoprotein expressed by macrophages present in lymphoid tissues (spleen, lymph node, thymus, and bone marrow), for which little functional and structural information is available (1). It belongs to the group B of the scavenger receptor cysteine-rich (SRCR) superfamily that includes the lymphocyte surface receptors CD5 and CD6 among others. AIM is able to bind to not only myelomonocytic and lymphoid cells (2), but also the surface of several Gram-positive and Gram-negative bacterial strains (3), which suggests that it may play an important role in the regulation of the innate and adaptive immune systems. It has been reported that AIM is present in IgM fraction, but not IgG or IgA fractions, from human serum (4). AIM is a circulating protein that may play a role in the homeostasis of IgM antibodies. In addition, it has been reported that AIM expression is induced in mouse macrophages in response to loading with highly oxidized low density lipoprotein (5), and that AIM is expressed in foam cells within atherosclerotic lesions. AIM may be feasible as a potential biomarker in the diagnosis and treatment of atopic dermatitis (6), although AIM was reported as candidate marker in asthma (7) and liver cirrhosis (8, 9)|
|Gene ID Human:||922|
|Gene ID Mouse:||11801|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||ELISA Kit|
There are no references for CircuLex Mouse AIM/CD5L/Spα ELISA kit at this time.