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|Background:||DUSP1 is a member of a family of dual-specificity phosphatases that dephosphorylate both phosphothreonine and phosphotyrosine residues and contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25-like (CH2) domain. DUSP1 is also known as MKP-1 (mitogenactivated protein (MAP) kinase phosphatase-1) and inactivates MAP kinase by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. The expression of DUSP1/MKP-1 is induced in human skin fibroblasts by oxidative/heat stress and growth factors. DUSP1/MKP-1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation via the dephosphorylation of MAP kinase. A recent study* also shows that DUSP1/MKP-1 is a key factor of major depressive disorder (MDD) and it may be a new drug targets for treating depression and possibly other mood disorders. * Duric V, Banasr M, Licznerski P, Schmidt HD, Stockmeier CA, Simen AA, Newton SS, Duman RS. A negative regulator of MAP kinase causes depressive behavior. Nat Med. 16: 1328-32, 2010.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
There are no references for CycLex Protein Phosphatase DUSP1/MKP-1 Fluorometric Assay Kit at this time.