Solutions for Life Science & Diagnostics
CycLex NAMPT Colorimetric Assay Kit
This Kit detects nicotinamide phosphoribosyltransferase (NAMPT) activity in recombinant NAMPT or endogenous NAMPT immunoprecipitated from cell extract.Additional Information
CycLex NAMPT Colorimetric Assay Kit Specifications
| Alternative Names: | NAMPT, NMNAT1 |
| Background: | Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B-cell colony-enhancing factor, is the rate-limiting enzyme that converts nicotinamide to nicotinamide mononucleotide (NMN) from nicotinamide in the salvage pathway of NAD+ biosynthesis in mammals. Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) converts NMN to NAD+. The expression of NAMPT is upregulated during activation of immune cells such as monocytes, macrophages, dendritic cells, T and B cells, as well as in amniotic epithelial cells upon stimulation with several inflammatory cytokines. NAMPT-specific inhibitor, FK866 was found to deplete intracellular NAD content, resulting in apoptotic cell death in many cancer cell lines without any DNA damaging effect. Recently, Nakahata K et al, demonstrated that NAMPT is required to modulate circadian gene expression and circadian oscillation of NAD+. |
| Gene ID Human: | 10135 |
| Gene ID Mouse: | 59027 |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Product Type: | Kit |
| Shipping: | dry ice |
| Size: | 100 assays |
| Status: | RUO |
| Storage: | -70℃ |
| Target: | NAMPT |
Applications:
There are no references for CycLex NAMPT Colorimetric Assay Kit at this time.
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