Solutions for Life Science & Diagnostics
Anti-CHIP (Mouse) mAb
Additional Information
Anti-CHIP (Mouse) mAb Specifications
| Background: | CHIP (carboxyl terminus of Hsc70-interacting protein) is a 35 kDa co-chaperone protein that interacts with Hsc70, Hsp70, and Hsp90. CHIP is a U-box dependent E3 ubiquitin ligase that accelerates ubiquitin-dependent degradation of chaperone substrates. CHIP binds directly to the C-terminus of Hsc70 and Hsp70 where it decreases ATPase activity and reduces overall chaperone efficiency. CHIP has also been reported to be involved in the degradation of c-ErbB2/c-Neu, the glucocorticoid receptor, and the cystic fibrosis transmembrane-conductance regulator. CHIP is highly expressed in brain, heart, and striated muscle |
| Clonality: | Monoclonal |
| Clone Number: | 12A11 |
| Formulation: | 1.0 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 10273 |
| Gene ID Mouse: | 56424 |
| Host Species: | Chicken |
| Immunogen: | Recombinant Mouse CHIP |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgY |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μg |
| Species Reactivities: | Human, Mouse |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | CHIP |
Applications: IP, WB
| IPP: | 10 ug/200 uL of cell extract from 5x106 |
| WB: | 1 ug/mL (for chemiluminescence detection system) |
There are no references for Anti-CHIP (Mouse) mAb at this time.
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