anti-Active Caspase-9 Specifications
|Background:||Caspases are synthesized as inactive pro-enzymes that are processed to active form in cells
undergoing apoptosis. Caspase-9 is an important member of the caspase family. Upon induction
of apoptosis, Cytochrome c released from mitochondria associates with pro-caspase-9 (47 kDa)
and Apaf-1. The complex processes pro-caspase-9 into a large subunit (37 kDa/17 kDa) and a
small subunit (10 kDa). Cleaved caspase-9 further processes other caspases including caspase-3
and caspase-6, to initiate a caspase cascade leading to apoptosis. The affinity purified antibody
recognizing the active forms of caspase-9 provides a new tool for identifying apoptotic cell
populations in both tissue sections and cultured cells.
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
Applications: WB, IP, IC
There are no references for anti-Active Caspase-9 at this time.