|Background:||Apoptosis occurs during normal cellular development and involves dramatic changes in cellular structure. Disruption of apoptosis may contribute to cancer as well as other autoimmune diseases. The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-1 (ICE, Interleukin-1Î²-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1Î² and IL-18 into active cytokines. Like other caspases, caspase-1 itself is synthesized as a pro-enzyme that is cleaved during activation into large (20 kDa) and small (10 kDa) subunits. The cellular role of caspase-1 appears limited to cytokine activation as they do not have obvious roles in apoptosis.
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
Applications: WB, IP, IH
There are no references for anti-Caspase-1 at this time.