Solutions for Life Science & Diagnostics
Anti-SLC33A1 (AT1) (Human) pAb
Additional Information
Anti-SLC33A1 (AT1) (Human) pAb Specifications
| Background: | Solute carrier family 33 member 1 (SLC33A1) is an acetyl-coA transporter (also known as AT1) that is widely distributed in human tissues, including those of the brain, heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas, and it participates in O-acetylation of membrane gangliosides. Defects in the SLC33A1 gene are observed in patients with autosomal-dominant spastic paraplegia of type 42 (SPG42). Spastic paraplegia is a neurodegenerative disorder characterized by slow, gradual, progressive weakness and spasticity of the lower limbs. Spinal motoneuronal axons are scarce and poorly organized in zebrafish lacking the slc33a1 gene as compared to wild-type zebrafish. The neurological disorders in the mutant fish can be overcome by injection of wild-type human SLC33A1 but not by injection of an SLC33A1 mutant with a S113R variation, which is one of the mutations found in SPG42 patients. |
| Clonality: | Polyclonal |
| Formulation: | In PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 9197 |
| Gene ID Mouse: | 11416 |
| Host Species: | Rabbit |
| Immunogen: | Human SLC33A1-derived synthetic peptide |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | Ig (aff.) |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 μL |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | SLC33A1/AT1 |
Applications: FCM, IC, IH
| FCM: | 1:500 |
| ICC: | 1:500 |
| IHC: | 1:500（Heat treatment is necessary for paraffin emb |
There are no references for Anti-SLC33A1 (AT1) (Human) pAb at this time.
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