An excitatory neurotransmitter glutamate is stored in synaptic vesicles. Excitatory neurons release glutamate by exocytosis into the synaptic cleft in response to neuronal stimulation. Members of the solute carrier family 17 are classified as vesicular glutamate transporters. These transporters participate in the accumulation of glutamate in synaptic vesicles. SLC17A6/VGLUT2 is predominantly expressed in the adult brain and plays a role in glutamate homeostasis in the central nervous system. In addition, SLC17A6/VGLUT2 mediates the transport of inorganic phosphate in a sodium-dependent manner.