Anti-SLC9A6/NHE6 polyclonal antibody Trial size
Code No: BMP049B
Gene/antigen ID number:
10479
Background:
SLC9A6, also known as NHE6, is a monovalent sodium-selective sodium/hydrogen exchanger (NHE) that is located on the membranes of intracellular organelles such as mitochondria and endosomes. NHEs are involved in a wide array of essential cellular processes, including control of cellular volume and intracellular pH, and reabsorption of sodium across the renal, intestinal, and other epithelia. The dysfunction of SLC9A6 by gene mutations results in an X-linked mental retardation syndrome that is characterized by microcephaly, epilepsy, ataxia, and absent speech and resembles Angelman syndrome.
Product Type:
Primary Antibody
Species Reactivities:
Human
Related Products:
BMP023 anti- SLC9A1/NHE1 (polyclonal)
References:
Gilfillan, G. D., et al., Am. J. Hum. Genet. 82, 1003-1010 (2008) Christianson, A. L., et al., J. Med. Genet. 36, 759-766 (1999) Numata, M., et al., J. Biol. Chem. 273, 6951-6959 (1998)
Formulation:
50 uL volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Reactivity:
This antibody can be used to stain endogenous antigen in paraffin embedded human tissues including brain by Immunohistochemistry. The reactivity has been confirmed by Immunocytochemistry, and intracellular Flow cytometry to detect the full length of human SLC9A6 transiently expressed in HEK 293T cells.
Intended Use:
For Research use only. Not for use in diagnostic procedure.
|