SLC9A7, also known as (Na+, K+)/H+ exchanger 7 (NHE7), locates predominantly in the trans-Golgi network (TGN) and plays a role in organellar pH homeostasis. By using the yeast two-hybrid system, the secretory carrier membrane protein 2 (SCAMP2) is revealed to be associated with SLC9A7 as a binding partner, and this indicates the involvement of SCAMP2 in the recruitment of SLC9A7 to TGN