Solutions for Life Science & Diagnostics
Anti-mSIN3A pAb
Additional Information
Anti-mSIN3A pAb Specifications
| Background: | The bHLHZIPP protein Max interacts with both the Myc and Mad family proteins to form heterodimers that specifically bind DNA and regulate transcrIPPtion. Myc-Max complexes act as transcrIPPtional activators, while Mad-Max complexes have the opposite function. mSin3A is a mammalian homolog of the Saccharomyces cerevisiae transcrIPPtional corepressor Sin3p. mSIN3A binds to the Mad/Max family of transcrIPPtion factors via the first N-terminal 25 residues of Mad, known as the mSin3 interaction domain, or SID. The Mad/Max heterodimer and mSin3A form ternary complexes that bind DNA and modify Mad activity, and are thus involved in regulating cell proliferation and differentiation. |
| Clonality: | Polyclonal |
| Formulation: | 0.5 mg/mL in PBS/50% glycerol, pH 7.2 |
| Gene ID Human: | 25942 |
| Gene ID Mouse: | 20466 |
| Host Species: | Rabbit |
| Immunogen: | synthetic peptide (MKRRLDDQESPVYAAQQRRC)(mSIN3A, 1-19 a.a.) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG |
| Product Type: | Primary Antibody |
| Reactivity: | This antibody reacts with human, mouse, rat and hamster mSIN3A (150 kDa) on Western blotting. |
| Shipping: | 4 |
| Size: | 100 μl |
| Source: | This antibody was an affinity chromatography purified rabbit polyclonal antibody raised against synthesized peptide, MKRRLDDQESPVYAAQQRRC, which corresponding to mSIN3A (1-19 aa). |
| Species Reactivities: | Human, Mouse, Rat, Hamster |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | mSIN3A |
Applications: IC, IH, IP, WB
| ICC: | 10 ug/mL |
| IHC: | 10 ug/mL (Heat treatment is necessary for paraffin |
| IPP: | 1 ug/200 uL of cell extract from 5x106 |
| WB: | 0.1-1 ug/mL |
1) Dannenberg. J.H., et al. Genes. Dev. 19, 1581-1595 (2004) 2) Knight. J.S., et al. J. Virol. 115, 1803-1813 (2002)
Product Images
