Phospho-c-Met [Tyr1003] Polyclonal Antibody
Phospho-c-Met [Tyr1003] Polyclonal Antibody Specifications
|Background:||Binding of scatter factor (SF)/hepatocyte growth factor (HGF) to the c-Met receptor tyrosine kinase (RTK) triggers receptor dimerization and phosphorylation on multiple residues within the juxtamembrane, catalytic core and cytoplasmic tail domains, thereby regulating receptor internalization, catalytic activity and multisubstrate docking. c-Met contains three tyrosines (Tyr-x-x-x-Tyr-Tyr motif) within the activation loop of the catalytic domain. This is also seen with the insulin receptor, insulin-like growth factor (IGF1) receptor and nerve growth factor (NGF) receptors/Trks, for which phosphorylation of all three tyrosines is required for full activation. With c-Met (and the related family member, RON) phosphorylation of tyrosines 1234 and 1235 has been shown to be important in receptor activation. Activation of the c-Met receptor results in binding and/or phosphorylation of many intracellular signaling proteins including multiple adaptor proteins (e.g., Grb2, Shc, Cbl, Crk, cortactin, paxillin, and Gab1), and a variety of other signal transducers (e.g., PI3-kinase, FAK, Src, ERK1&2, JNK, PLC-, and STAT3). Tyrosine 1003 is a membrane proximal negative regulatory phosphorylation site that binds Cbl, and has been shown to be located near an oncogenic mutation site in c-Met.
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
There are no references for Phospho-c-Met [Tyr1003] Polyclonal Antibody at this time.