- Diagnostic Products
- Research Products
|Background:||Cortactin is an 80/85 kDa cytoskeleton protein that facilitates assembly of cortical actin. Cortactin is widely expressed in most adherent cells and is a prominent substrate of protein-tyrosine kinase Src in vivo and in vitro. The protein sequence of cortactin contains multiple amino-terminal tandem repeats of a unique 37-amino acid sequence, which associates with actin, and a Src homology 3 (SH3) domain at the carboxyl terminus. Between the repeat and the SH3 domain, there is an Î±-helical structure followed by a proline-rich region. Between the proline-rich region and the SH3 domain, there are Src phosphorylation sites at tyrosines 421, 466 and 482 (421, 470 and 486 in the human sequence) that when phosphorylated, attenuate the cross-linking of F-actin into meshworks with the Arp2/3 complex, and are required for cell movement and metastasis.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
There are no references for Phospho-Cortactin [Tyr421] Polyclonal Antibody at this time.