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Phospho-IRS-1 [Tyr896] Polyclonal Antibody

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SKUNameSizeQtyPriceAdd to Cart
AT-7152 Phospho-IRS-1 [Tyr896] Polyclonal Antibody 100 µL $374.74

Additional Information

Phospho-IRS-1 [Tyr896] Polyclonal Antibody Specifications

Background:Insulin Receptor Substrate-1 (IRS-1) is a 165 kDa multi-phosphorylated cytoplasmic docking protein involved in the regulation of metabolism and proliferation by insulin, IL-4, and other cytokines. Insulin binding to the insulin receptor activates the catalytic domain and causes phosphorylation on tyrosine residues of IRS proteins, which in turn serve to recruit a variety of Src homology-2 (SH2) domain-containing proteins such as PI3 kinase, Grb-2, SHP-2, Nck and Crk. These proteins further propagate intracellular signaling, culminating in both metabolic and growth-promoting functions of IRS-1. Tyr896 of IRS-1 is a Grb-2 SH2 domain binding site.
Host Species:Rabbit
Regulatory Statement:For Research Use Only. Not for use in diagnostic procedures.
Product Type:Primary Antibody
Size:100 µL
Species Reactivities:H
Target:Phospho-IRS-1 [Tyr896]

Applications: WB

There are no references for Phospho-IRS-1 [Tyr896] Polyclonal Antibody at this time.