- Diagnostic Products
- Research Products
|Background:||Insulin Receptor Substrate-1 (IRS-1) is a 165 kDa multi-phosphorylated cytoplasmic docking protein involved in the positive regulation of metabolism and proliferation by insulin, IL-4 and other cytokines. Insulin binding to the insulin receptor activates the catalytic domain and causes phosphorylation on tyrosine residues of IRS proteins, which in turn serve to recruit a variety of Src homology-2 (SH2) domain-containing proteins such as PI3-kinase, Grb2, SHP-2, Nck and Crk. These proteins further propagate intracellular signaling, culminating in both metabolic and growth-promoting functions of IRS-1. Phosphorylated tyrosine 612 of IRS-1 is a pYMxM consensus motif PI3-kinase binding site. This binding leads to the activation of Akt.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
There are no references for Phospho-IRS-1 [Tyr612] Polyclonal Antibody at this time.