Solutions for Life Science & Diagnostics
Phospho-IRS-1 [Tyr612] Polyclonal Antibody
Additional Information
Phospho-IRS-1 [Tyr612] Polyclonal Antibody Specifications
| Background: | Insulin Receptor Substrate-1 (IRS-1) is a 165 kDa multi-phosphorylated cytoplasmic docking protein involved in the positive regulation of metabolism and proliferation by insulin, IL-4 and other cytokines. Insulin binding to the insulin receptor activates the catalytic domain and causes phosphorylation on tyrosine residues of IRS proteins, which in turn serve to recruit a variety of Src homology-2 (SH2) domain-containing proteins such as PI3-kinase, Grb2, SHP-2, Nck and Crk. These proteins further propagate intracellular signaling, culminating in both metabolic and growth-promoting functions of IRS-1. Phosphorylated tyrosine 612 of IRS-1 is a pYMxM consensus motif PI3-kinase binding site. This binding leads to the activation of Akt. |
| Clonality: | Polyclonal |
| Host Species: | Rabbit |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 µL |
| Species Reactivities: | H |
| Status: | RUO |
| Storage: | -20 |
| Target: | Phospho-IRS-1 [Tyr612] |
Applications: WB
There are no references for Phospho-IRS-1 [Tyr612] Polyclonal Antibody at this time.
