Phospho-PLC gamma-1 [Tyr783] Polyclonal Antibody
Phospho-PLC gamma-1 [Tyr783] Polyclonal Antibody Specifications
|Background:||Phosphoinositide-specific phospholipase C (PLC) is a family of proteins that hydrolyze phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5- trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG is a direct activator of protein kinase C (PKC). These processes are involved in the control of multiple cellular activities such as cell proliferation, growth and differentiation. PLCï§-1 is a 135 kDa ubiquitously expressed isozyme that is activated by phosphorylation of tyrosine 783 and interacts with growth factor receptors (EGFR, PDGFR, etc.) and adhesion/ cytoskeletal proteins (FAK, paxillin) to influence a multiple number of signaling pathways.
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||H, M|
|Target:||Phospho-PLC gamma-1 [Tyr783]|
There are no references for Phospho-PLC gamma-1 [Tyr783] Polyclonal Antibody at this time.