Solutions for Life Science & Diagnostics

Phospho-ERK1/2 [Thr202/185, Tyr204/187] Polyclonal Antibody

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AT-7139 Phospho-ERK1/2 [Thr202/185, Tyr204/187] Polyclonal Antibody 10 blot $346.50

Additional Information

Phospho-ERK1/2 [Thr202/185, Tyr204/187] Polyclonal Antibody Specifications

Background:ERK (extracellular signal-regulated kinase), also known as MAPK (mitogen-activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth, differentiation and the cytoskeleton. ERK1 and ERK2 are fully activated by phosphorylation within a Thr-Glu-Tyr motif of the activation loop on both a threonine and a tyrosine residue by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of the ERK1 and ERK2 enzymes.
Clonality:Polyclonal
Host Species:Rabbit
Regulatory Statement:For Research Use Only. Not for use in diagnostic procedures.
Isotype:IgG
Product Type:Primary Antibody
Shipping:4
Size:10 blot
Species Reactivities:H, M, R, ch, b, dm, ce, x
Status:RUO
Storage:-20
Target:Phospho-ERK1/2 [Thr202/185, Tyr204/187]

Applications: IH, WB

There are no references for Phospho-ERK1/2 [Thr202/185, Tyr204/187] Polyclonal Antibody at this time.