Solutions for Life Science & Diagnostics

Phospho-PKR [Thr451] Polyclonal Antibody

Ordering Guide

SKUNameSizeQtyPriceAdd to Cart
AT-7137 Phospho-PKR [Thr451] Polyclonal Antibody 100 µL $397.45

Additional Information

Phospho-PKR [Thr451] Polyclonal Antibody Specifications


Double-stranded RNA-dependent protein kinase (PKR) is a 68 kDa protein that is induced by interferon and double-stranded RNAs (dsRNA) produced in virus-infected cells. Two dsRNA-binding domains in the N-terminus interact with dsRNA to modify the conformation of PKR and allow it to undergo autophosphorylation and activation. Once activated, PKR phosphorylates eIF2, leading to inhibition of protein synthesis, growth suppression, and apoptosis induction. The phosphorylation of two sites in the activation loop of the kinase domain, threonines 446 and 451, is critical for high level catalytic activity.

Host Species:Rabbit
Regulatory Statement:For Research Use Only. Not for use in diagnostic procedures.
Product Type:Primary Antibody
Size:100 µL
Species Reactivities:H, M
Target:Phospho-PKR [Thr451]

Applications: WB, IH

There are no references for Phospho-PKR [Thr451] Polyclonal Antibody at this time.