- Diagnostic Products
- Research Products
|Background:||Double-stranded RNA-dependent protein kinase (PKR) is a 68 kDa protein that is induced by interferon and double-stranded RNAs (dsRNA) produced in virus-infected cells. Two dsRNA-binding domains in the N-terminus interact with dsRNA to modify the conformation of PKR and allow it to undergo autophosphorylation and activation. Once activated, PKR phosphorylates eIF2ï¡, leading to inhibition of protein synthesis, growth suppression, and apoptosis induction. The phosphorylation of two sites in the activation loop of the kinase domain, threonines 446 and 451, is critical for high level catalytic activity.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||H, M|
Applications: WB, IH
There are no references for Phospho-PKR [Thr451] Polyclonal Antibody at this time.