Solutions for Life Science & Diagnostics

Phospho-GSK-3alpha [Tyr279] / beta[Tyr216] Polyclonal Antibody

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AT-7122 Phospho-GSK-3alpha [Tyr279] / beta[Tyr216] Polyclonal Antibody 100 µL $346.50

Additional Information

Phospho-GSK-3alpha [Tyr279] / beta[Tyr216] Polyclonal Antibody Specifications

Background:Glycogen synthase kinase-3β (GSK-3β) is a non-receptor serine/threonine kinase that plays an important role in the regulation of cell fate, tumorignenesis, and neuronal plasticity. GSK-3 is present in 2 isoforms, α (51kDa) and β (47kDa). GSK-3α can be activated by phosphorylation of tyrosine 279 (tyrosine 216 of GSK-3β) of the kinase activation loop by focal adhesion kinase (FAK) or proline-rich/Ca2+-activated tyrosine kinase (Pyk2), inhibiting glycogen synthesis which induces apoptosis. GSK-3β also hyperphosphorylates Tau, a microtubule binding protein, which results in a paired helical formation. This formation is used as a marker in the pathogenesis of Alzheimer’s Disease.
Clonality:Polyclonal
Host Species:Rabbit
Regulatory Statement:For Research Use Only. Not for use in diagnostic procedures.
Isotype:IgG
Product Type:Primary Antibody
Shipping:4
Size:100 µL
Species Reactivities:H, M, R
Status:RUO
Storage:-20
Target:Phospho-GSK-3alpha [Tyr279] / beta[Tyr216]

Applications: WB, ELISA

There are no references for Phospho-GSK-3alpha [Tyr279] / beta[Tyr216] Polyclonal Antibody at this time.