Solutions for Life Science & Diagnostics
Phospho-GSK-3alpha [Tyr279] / beta[Tyr216] Polyclonal Antibody
Additional Information
Phospho-GSK-3alpha [Tyr279] / beta[Tyr216] Polyclonal Antibody Specifications
| Background: | Glycogen synthase kinase-3β (GSK-3β) is a non-receptor serine/threonine kinase that plays an important role in the regulation of cell fate, tumorignenesis, and neuronal plasticity. GSK-3 is present in 2 isoforms, α (51kDa) and β (47kDa). GSK-3α can be activated by phosphorylation of tyrosine 279 (tyrosine 216 of GSK-3β) of the kinase activation loop by focal adhesion kinase (FAK) or proline-rich/Ca2+-activated tyrosine kinase (Pyk2), inhibiting glycogen synthesis which induces apoptosis. GSK-3β also hyperphosphorylates Tau, a microtubule binding protein, which results in a paired helical formation. This formation is used as a marker in the pathogenesis of Alzheimer’s Disease. |
| Clonality: | Polyclonal |
| Host Species: | Rabbit |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 µL |
| Species Reactivities: | H, M, R |
| Status: | RUO |
| Storage: | -20 |
| Target: | Phospho-GSK-3alpha [Tyr279] / beta[Tyr216] |
Applications: WB, ELISA
There are no references for Phospho-GSK-3alpha [Tyr279] / beta[Tyr216] Polyclonal Antibody at this time.
