Phospho-GSK-3alpha [Tyr279] / beta[Tyr216] Polyclonal Antibody
Phospho-GSK-3alpha [Tyr279] / beta[Tyr216] Polyclonal Antibody Specifications
|Background:||Glycogen synthase kinase-3Î² (GSK-3Î²) is a non-receptor serine/threonine kinase that plays an important role in the regulation of cell fate, tumorignenesis, and neuronal plasticity. GSK-3 is present in 2 isoforms, Î± (51kDa) and Î² (47kDa). GSK-3Î± can be activated by phosphorylation of tyrosine 279 (tyrosine 216 of GSK-3Î²) of the kinase activation loop by focal adhesion kinase (FAK) or proline-rich/Ca2+-activated tyrosine kinase (Pyk2), inhibiting glycogen synthesis which induces apoptosis. GSK-3Î² also hyperphosphorylates Tau, a microtubule binding protein, which results in a paired helical formation. This formation is used as a marker in the pathogenesis of Alzheimerâ€™s Disease.
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||H, M, R|
|Target:||Phospho-GSK-3alpha [Tyr279] / beta[Tyr216]|
There are no references for Phospho-GSK-3alpha [Tyr279] / beta[Tyr216] Polyclonal Antibody at this time.