- Diagnostic Products
- Research Products
|Background:||Microtubule-associated protein kinase kinase 1 (MEK1 or MAPKK1) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1&2/MAPK enzymes by phosphorylating both residues within the threonine â€“ glutamic acid â€“ tyrosine (TEY) motif in the activation loop. MEK1&2 are also activated by dual-phosphorylation, which occurs on serines 218 and 222, in the activation loop of the MEKs. Serine 298 of MEK1 is phosphorylated by PAK proteins, which promote MEK1 binding to c-Raf and its subsequent phosphorylation of MEK1, leading to activation of the MAPK pathway.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||H, M, R|
There are no references for Phospho-MEK1 [Ser298] Polyclonal Antibody at this time.