- Diagnostic Products
- Research Products
|Background:||Tau is a neuronal microtubule-associated protein found predominantly on axons and functions to promote tubulin polymerization and stabilze microtubules. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimerï¿½s disease (AD) brain. Hyperphosphorylated Tau is also found in neurofibrillary lesions in a range of other central nervous system disorders. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases including GSK-3?, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II (CK2), phosphorylate Tau. Threonine 231 is phosphorylated by GSK-3?, cdk5 and cdk1, and has been shown to be involved in the pre-tangle process in AD.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||H, M, R|
Applications: WB, IH, ELISA
There are no references for Phospho-Tau [Ser199] Polyclonal Antibody at this time.