beta-Amyloid (Abeta) (pan) Polyclonal Antibody
beta-Amyloid (Abeta) (pan) Polyclonal Antibody Specifications
|Background:||Alzheimerï¾’s disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques is a 39-42 amino acid peptide (?-amyloid/A?). A? occurs in two predominant forms with different COOH-termini, A? 40 and A? 42, and overproduction of A? 42 has been suggested to be the cause of familial early-onset AD. A? generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: ?-secretase and ?-secretase. Recent studies suggest that a transmembrane aspartic protease, termed beta-site APP-cleaving enzyme (BACE), functionally acts as the ?-secretase.
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
There are no references for beta-Amyloid (Abeta) (pan) Polyclonal Antibody at this time.