Solutions for Life Science & Diagnostics
IGF-1R (beta-Subunit) Monoclonal Antibody
Additional Information
IGF-1R (beta-Subunit) Monoclonal Antibody Specifications
| Background: | Insulin-like growth factor-1 receptor (IGF-1R, also known as CD221), a member of the tyrosine kinase superfamily, is a broadly expressed transmembrane receptor that plays a key role in supporting cell growth and differentiation, and imparts resistance to apoptosis. IGF-1R is synthesized as a single polypeptide that is glycosylated and proteolytically cleaved to yield a disulfide-linked tetrameric receptor composed of two α-subunits and two β-subunits, arranged in the configuration α-β-β-α. IGF-1R’s α-subunits (135 kDa) mediate ligand binding, and are entirely extracellular. IGF-1R’s β-subunits (90 kDa) each possess an extracellular domain, a single transmembrane domain, and a cytoplasmic portion. Three polypeptide ligands for IGF-1R have been identified: IGF-1, IGF-2, and insulin. IGF-1’s binding to the α-subunits of the receptor induces a conformational change, resulting in the trans-autophosphorylation of three tyrosine residues (1131, 1135, and 1136) and activation. Activated IGF-1R phosphorylates substrate proteins, including Shc and insulin receptor substrates (IRS) 1, 2, 3, and 4, and recruits 14-3-3 proteins. |
| Clonality: | Monoclonal |
| Clone Number: | 194Q13 |
| Host Species: | Mouse |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG2b k |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 µg |
| Species Reactivities: | H, M, R |
| Status: | RUO |
| Storage: | -20 |
| Target: | IGF-1R (beta-Subunit) |
Applications: WB
There are no references for IGF-1R (beta-Subunit) Monoclonal Antibody at this time.
