- Diagnostic Products
- Research Products
|Background:||Insulin-like growth factor-1 receptor (IGF-1R, also known as CD221), a member of the tyrosine kinase superfamily, is a broadly expressed transmembrane receptor that plays a key role in supporting cell growth and differentiation, and imparts resistance to apoptosis. IGF-1R is synthesized as a single polypeptide that is glycosylated and proteolytically cleaved to yield a disulfide-linked tetrameric receptor composed of two Î±-subunits and two Î²-subunits, arranged in the configuration Î±-Î²-Î²-Î±. IGF-1Râ€™s Î±-subunits (135 kDa) mediate ligand binding, and are entirely extracellular. IGF-1Râ€™s Î²-subunits (90 kDa) each possess an extracellular domain, a single transmembrane domain, and a cytoplasmic portion. Three polypeptide ligands for IGF-1R have been identified: IGF-1, IGF-2, and insulin. IGF-1â€™s binding to the Î±-subunits of the receptor induces a conformational change, resulting in the trans-autophosphorylation of three tyrosine residues (1131, 1135, and 1136) and activation. Activated IGF-1R phosphorylates substrate proteins, including Shc and insulin receptor substrates (IRS) 1, 2, 3, and 4, and recruits 14-3-3 proteins.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||H, M, R|
There are no references for IGF-1R (beta-Subunit) Monoclonal Antibody at this time.