Solutions for Life Science & Diagnostics

IGF-1R (beta-Subunit) Monoclonal Antibody

Ordering Guide

SKUNameSizeQtyPriceAdd to Cart
AT-2041 IGF-1R (beta-Subunit) Monoclonal Antibody 100 µg $408.81

Additional Information

IGF-1R (beta-Subunit) Monoclonal Antibody Specifications

Background:Insulin-like growth factor-1 receptor (IGF-1R, also known as CD221), a member of the tyrosine kinase superfamily, is a broadly expressed transmembrane receptor that plays a key role in supporting cell growth and differentiation, and imparts resistance to apoptosis. IGF-1R is synthesized as a single polypeptide that is glycosylated and proteolytically cleaved to yield a disulfide-linked tetrameric receptor composed of two α-subunits and two β-subunits, arranged in the configuration α-β-β-α. IGF-1R’s α-subunits (135 kDa) mediate ligand binding, and are entirely extracellular. IGF-1R’s β-subunits (90 kDa) each possess an extracellular domain, a single transmembrane domain, and a cytoplasmic portion. Three polypeptide ligands for IGF-1R have been identified: IGF-1, IGF-2, and insulin. IGF-1’s binding to the α-subunits of the receptor induces a conformational change, resulting in the trans-autophosphorylation of three tyrosine residues (1131, 1135, and 1136) and activation. Activated IGF-1R phosphorylates substrate proteins, including Shc and insulin receptor substrates (IRS) 1, 2, 3, and 4, and recruits 14-3-3 proteins.
Clone Number:194Q13
Host Species:Mouse
Regulatory Statement:For Research Use Only. Not for use in diagnostic procedures.
Isotype:IgG2b k
Product Type:Primary Antibody
Size:100 µg
Species Reactivities:H, M, R
Target:IGF-1R (beta-Subunit)

Applications: WB

There are no references for IGF-1R (beta-Subunit) Monoclonal Antibody at this time.