- Diagnostic Products
- Research Products
|Background:||The 12G5 mAb reacts with the chemokine receptor CXCR4, previously called Fusin or LESTER. CXCR4 is a seven transmembrane domain receptor, which is involved in the signaling of the chemokine, Stromal cell-derived factor-1 (SDF-1). SDF-1 is an efficacious chemoattractant for lymphocytes and monocytes but is inactive on neutrophils. CXCR4 expression on T cells and on macrophages and its absence on neutrophilic and eosinophilic granulocytes mirrors the chemotactic activity of SDF-1 for leukocyte subsets. The CXCR4 receptor was shown to serve as a cofactor for HIV-1 isolates that are tropic for T cell lines.|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
|Species Reactivities:||H, mk|
Applications: FCM, IH
There are no references for CXCR4 Monoclonal Antibody at this time.