Solutions for Life Science & Diagnostics

Anti-p62 (SQSTM1) pAb

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PM045 Anti-p62 (SQSTM1) pAb 100 µL $335.27

Additional Information

Anti-p62 (SQSTM1) pAb Specifications

Alternative Names:sequestosome 1, p60, p62, A170, OSIL, PDB3, ZIP3, p62B/Osi, A170, STAP, OSF-6/Osi, ZIP
Background:p62/SQSTM1 interacts with various molecular groups such as RIP, TRAF6, ERK, aPKCs, and poly-ubiquitin through PB1 domain, Zn finger domain, and UBA domain.@This protein directly interacts with LC3, which is localized on autophagosome membrane, and is degradated by autophagic-lysosome pathway. p62 regulates ubiquitin-positive protein aggregates caused by autophagy deficiency.
Clone Number:Polyclonal
Formulation:PBS/50% glycerol, pH 7.2
Gene ID Human:8878
Gene ID Mouse:18412
Gene ID Rat:113894
Host Species:Rabbit
Immunogen:Recombinant Human p62 (120-440 a.a.)
Regulatory Statement:For Research Use Only. Not for use in diagnostic procedures.
Product Type:Primary Antibody
Size:100 µL
Species Reactivities:Human,Mouse,Rat,Hamster

Applications: WB,IPP,ICC,IHC

IHC:1:1,000 (Heat treatment is necessary for paraffin
IPP:2 µL/300 µL of cell extract from 1x10<
  • Waguri S, Komatsu M. Biochemical and morphological detection of inclusion bodies in autophagy-deficient mice. Methods Enzymol. 453, 181-96 (2009) (PMID:19216907)Application: WB/IHC
  • Otomo T et al. Inhibition of autophagosome formation restores mitochondrial function in mucolipidosis II and III skin fibroblasts. Mol Genet Metab. 98, 393-9 (2009) (PMID:19656701)Application: WB
  • Dupont N et al. Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe. 6, 137-49 (2009) (PMID:19683680)Application: ICC
  • Ogata T et al. Fasting-related autophagic response in slow- and fast-twitch skeletal muscle. Biochem Biophys Res Commun. 394, 136-40 (2010) (PMID:20184860)Application: WB
  • Urbanczyk A et al. PKCƒÄ-interacting protein ZIP3 is generated by intronic polyadenylation, and is expressed in the brain and retina of the rat. Biochem J. 433, 43-50 (2011) (PMID:20979579)Application: IHC
  • Itakura E, Mizushima N. p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol. 192, 17-27 (2011) (PMID:21220506)Application: WB
  • Lee EJ, Tournier C. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 7 689-95 (2011) (PMID:21460635)Application: WB
  • Higaki K et al. Chemical chaperone therapy: chaperone effect on mutant enzyme and cellular pathophysiology in ƒÀ-galactosidase deficiency. Hum Mutat. 32, 843-52 (2011) (PMID:21520340)Application: WB/ICC
  • Myeku N, Figueiredo-Pereira ME. Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. J Biol Chem. 286, 22426-40 (2011) (PMID:21536669)Application: WB/ICC
  • Takamura A et al. Lysosomal accumulation of Trk protein in brain of GM1 -gangliosidosis mouse and its restoration by chemical chaperone. J Neurochem. 118, 399-406 (2011) (PMID:21574998)Application: WB
  • Huang Y et al. PML-RARƒ¿ enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. Autophagy 7, 1132-44 (2011) (PMID:21673516)Application: WB
  • Huang C et al. Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS One 6, e20975 (2011) (PMID:21687634)Application: ICC
  • Osawa Y et al. L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. J Biol Chem. 286, 34800-8 (2011) (PMID:21841000)Application: WB
  • Frankel LB et al. microRNA-101 is a potent inhibitor of autophagy. EMBO J. 30, 4628-41 (2011) (PMID:21915098)Application: WB
  • Takaesu G et al. TGFƒÀ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy. J Biochem. 151, 157-66 (2012) (PMI

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    Anti-p62 (SQSTM1) pAb