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Product Catalog |
Atg12 monoclonal anitbody(clone:6E5) : Trial SizeCode No: M154-3B
Target:
Atg12 Background:
Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Autophagy has two ubiquitin-like conjugation systems, the Atg12 and LC3-II systems. In the Atg12 conjugation system, the Atg12-Atg5-Atg16L forms 800 kDa complex that elongates autophagic isolation membrane. After completion of the formation of the autophagosome, the Atg12-Atg5-Atg16L complex dissociates from the membrane.
Size:
10 μg
Application:
IPP
Application:
WB
Clone Number:
6.00E+005
Product Type:
Primary Antibody
Host Species:
Mouse
Species Reactivities:
Human
Species Reactivities:
Mouse
Isotype:
IgG1 k
Storage Temp. (°C):
-20
Shipping Temp. (°C):
4 References:
1) Mizushima, N., et al., J. Cell Sci. 116, 1679-1688 (2003) Reactivity:
This antibody reacts with human Atg5-Atg12　complex (55 kDa) on Western blotting. Because almost all Atg12 exist in the form of Atg5-Atg12 complex, it is difficult to detect the monomeric Atg12.
Intended Use:
For Research use only. Not for use in diagnostic procedure. |
