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CDC25A(DCS-124) Monoclonal Antibody : Trial Size

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Code No: K0073-3S
Datasheet: 
application/pdf iconK0073-3S.pdf
Target: 

CDC25A (DCS-124)

Background: 

The members of the CDC25 family, CDC25A, CDC25B, and CDC25C, activate the cyclin-dependent kinases at different points in the cell cycle by dephosphorylating key proteins. The ~65 kDa CDC25A protein is a tyrosine phosphatase that regulates the G1/S transition by activating cyclin E/Cdk2 and cyclin A/Cdk2 complexes, which are required for DNA synthesis. CDC25A acts as a checkpoint to prevent DNA replication following DNA damage. DNA damage induces phosphorylation of CDC25A, resulting in its rapid degradation via the ubiquitin-proteosome pathway, and thus silencing Cdk2 activity.

Size: 
10 µg
Application: 
WB
Application: 
IPP
Clone Number: 
DCS-124
Concentration: 
0.2 mg/mL
Product Type: 
Primary Antibody
Host Species: 
Mouse
Species Reactivities: 
Human
Species Reactivities: 
Mouse
Species Reactivities: 
Rat
Isotype: 
IgG2a
Storage Temp. (°C): 
4
Shipping Temp. (°C): 
4
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References: 

1) Mailand, N., et al., EMBO J. 21, 5911-5920 (2002)
2) Mailand, N., et al., Science 288, 1425-1429 (2000)
3) Santoni-Rugiu, E., et al., Mol. Cell. Biol. 20, 3497-3509 (2000)

Formulation: 
10 g IgG in 50 L volume of PBS containing 1% BSA, 10% glycerol and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain.
Reactivity: 
This antibody reacts with human, mouse and rat CDC25A on Western blotting and ImmunoprecIPPitation.
Intended Use: 
For Research use only. Not for use in diagnostic procedure.
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