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Product Catalog |
CDC25A(DCS-121) Monoclonal Antibody : Trial SizeCode No: K0072-3S
Target:
CDC25A (DCS-121) Background:
The members of the CDC25 family, CDC25A, CDC25B, and CDC25C, activate the cyclin-dependent kinases at different points in the cell cycle by dephosphorylating key proteins. The ~65 kDa CDC25A protein is a tyrosine phosphatase that regulates the G1/S transition by activating cyclin E/Cdk2 and cyclin A/Cdk2 complexes, which are required for DNA synthesis. CDC25A acts as a checkpoint to prevent DNA replication following DNA damage. DNA damage induces phosphorylation of CDC25A, resulting in its rapid degradation via the ubiquitin-proteosome pathway, and thus silencing Cdk2 activity.
Size:
10 µg
Application:
WB
Application:
IPP
Application:
IHC
Clone Number:
DCS-121
Concentration:
0.2 mg/mL
Product Type:
Primary Antibody
Host Species:
Mouse
Species Reactivities:
Human
Species Reactivities:
Mouse
Species Reactivities:
Rat
Isotype:
IgG2a
Storage Temp. (°C):
4
Shipping Temp. (°C):
4 References:
1) Berthet, C., et al., PNAS 102, 13634-13639 (2005) Formulation:
10 g IgG in 50 L volume of PBS containing 1% BSA, 10% glycerol and 0.1% sodium azide as preservative.Sodium azide has been reported to form potentially explosive lead or copper azide in plumbing. To prevent forming of these compounds, flush drains enough after disposing of solutions containing sodium azide.
Reactivity:
This antibody reacts with human, mouse and rat CDC25A.
Intended Use:
For Research use only. Not for use in diagnostic procedure. |
