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Product Catalog |
CDC6 Monoclonal Antibody : Trial SizeCode No: K0069-3S
Target:
CDC6 Background:
Cell Division Cycle 6 (CDC6) is an approximately 62 kDa nuclear protein involved in DNA replication initiation that is expressed only in proliferating cells. Along with minichromosome maintenance (MCM) and Origin Recognition Complex (ORC), CDC6 is assembled onto chromatin to form a pre-replicative complex. In the absence of CDC6, cells fail to initiate DNA replication and undergo a "reductional" mitosis, in which the unreplicated chromosomes are randomly segregated to the spindle poles. CDC6 is activated at the G1/S phase of the cell cycle by the activity of the transcrIPPtion factor E2F3. CDC6 interacts directly with the cyclin A/Cdk2 complex, resulting in phosphorylation of CDC6 and translocation to the cytoplasm. Since down-regulation of CDC6 by Cdks restricts replication to only once per cell cycle, mutations in CDC6 may play an important role in cancer and tumorigenesis.
Size:
10 µg
Application:
WB
Application:
IPP
Clone Number:
DCS-180
Concentration:
0.2 mg/mL
Product Type:
Primary Antibody
Host Species:
Mouse
Species Reactivities:
Human
Species Reactivities:
Rat
Isotype:
IgG1
Storage Temp. (°C):
4
Shipping Temp. (°C):
4 References:
1) Petersen, B.O., et al. EMBO.J. 18, 396-410 (1999) Formulation:
10 g IgG in 50 L volume of PBS containing 1% BSA, 10% glycerol and 0.1% sodium azide as preservative. Sodium azide has been reported to form potentially explosive lead or copper azide in plumbing. To prevent forming of these compounds, flush drains enough after disposing of solutions containing sodium azide.
Reactivity:
This antibody reacts with human and rat CDC6.
Intended Use:
For Research use only. Not for use in diagnostic procedure. |
