Angiogenesis
Apoptosis
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Cell Surface Antigens
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Product Catalog |
CDK4 Monoclonal Antibody : Trial SizeCode No: K0065-3S
Target:
Cdk4 Background:
Cdk4 (Cyclin-Dependent Kinase 4) is a 34 kDa kinase involved in the control of cell proliferation and progression between the G1 and S phases of the cell cycle. Cdk4 acts as a G1 checkpoint; it is constitutively expressed and the assembly of cyclin D/Cdk4 complexes is the rate-limiting step in progression through the G1 stage of the cell cycle. p16, a putative tumor suppressor, also plays a role in cell cycle regulation by binding to and inhibiting Cdk4 in competition with cyclin D. Upregulation of the cyclin D/Cdk4/6 complex is associated with the early stages of neuronal apoptosis, and the cyclin D/Cdk4 complex phosphorylates pRB (retinoblastoma gene product). Since p16 and pRB activity are inactivated or modified in a wide variety of human cancers, Cdk inhibitors such as Cdk4 may have therapeutic potential as anti-cancer drugs.
Size:
10 µg
Application:
WB
Application:
IHC
Clone Number:
DCS-156
Concentration:
0.2 mg/mL
Product Type:
Primary Antibody
Host Species:
Mouse
Species Reactivities:
Human
Species Reactivities:
Mouse
Isotype:
IgG1
Storage Temp. (°C):
4
Shipping Temp. (°C):
4 Pictures:
 References:
1) Rheinwald, J. G., et al., Mol. Cell. Biol. 22, 5157-5172 (2002) Formulation:
10 g IgG in 50 L volume of PBS containing 1% BSA, 10% glycerol and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain.
Reactivity:
This antibody reacts with human and mouse Cdk4. It is reported that DCS-156 recognizes the C-terminus of human Cdk4 (270-290 aa) in the reference number 2).
Intended Use:
For Research use only. Not for use in diagnostic procedure. |
