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Product Catalog |
Cyclin D2 Monoclonal Antibody : Trial SizeCode No: K0064-3S
Target:
Cyclin D2 Background:
Cyclin D2 (34 kDa) is one of three D-type cyclins that are synthesized in G1 phase and induced in response to agents that promote re-entry into the cell cycle. D-type cyclins assemble with cyclin-dependent kinases Cdk4 and Cdk6 to form complexes that phosphorylated key substrates, including the retinoblastoma protein Rb, involved in proliferation. Generally, D cyclins appear late in the G1 phase of the cell cycle; however, cyclin D2 accumulates in G0 and at the G1/S interface. A role for cyclin D2 has been suggested in differentiation and oncogenic transformation. Cyclin D2 is expressed in macrophages in response to CSF-1 stimulation, and overexpression of cyclin D2 is associated with increased in vivo invasiveness of human squamous carcinoma cells.
Size:
10 µg
Application:
WB
Application:
IPP
Clone Number:
DCS-5
Concentration:
0.2 mg/mL
Product Type:
Primary Antibody
Host Species:
Mouse
Species Reactivities:
Human
Species Reactivities:
Mouse
Isotype:
IgG2b
Storage Temp. (°C):
4
Shipping Temp. (°C):
4 References:
1) Kohoutek, J., et al., Biol. Reprod. 70, 139-145 (2004) Formulation:
10 g IgG in 50 L volume of PBS containing 1% BSA. 10% glycerol and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain.
Reactivity:
This antibody reacts with human and mouse cyclin D2 on Western blotting and ImmunoprecIPPitation.
Intended Use:
For Research use only. Not for use in diagnostic procedure. |
