Internucleosomal DNA fragmentation is a hallmark of apoptosis in mammalian cells. MBL’s Apoptotic DNA Ladder Extraction Kit provides an easy and sensitive means for isolation and detection of DNA fragmentation in apoptotic cells. The new procedure selectively isolates DNA ladders without interference of regular genomic DNA, which significantly improves detection sensitivity. The kit can detect apoptotic DNA ladder from both tissues and cells that contains even as little as 5% or less apoptotic cell population. The extracted apoptotic DNA ladder fragments can be easily visualized by agarose gel electrophoreses.