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|Background:||Members of the S100 protein family are low molecular mass acidic proteins characterized by cell-type-specific expression and the presence of 2 EF-hand calcium-binding domains with different affinities for calcium. Elevated levels of one S100 protein, S100A4, are closely associated with the process of metastasis in breast and other cancer cells in rodent animal models and in human cancer specimens. S100A4 or its mRNA is found at an elevated level in metastatic relative to non-metastatic rat (1) and mouse (2) tumor cell lines and malignant relative to benign human breast tumors. Elevation of the level of rat (3) or human (4) S100A4 in benign rat mammary tumor cells results in the acquisition of metastatic capability by some of the cells. In transgenic mouse models of breast cancer, elevated levels of S100A4 in neu oncogene-induced, or in murine mammary tumor virus-induced, benign mammary tumors yield lung metastases. In colorectal adenocarcinoma specimens, elevated levels of immunocytochemically detected S100A4 are associated with the more malignant carcinomatous regions of the primary tumors and with liver metastases|
|Gene ID Human:||6275|
|Gene ID Mouse:||20198|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
There are no references for CircuLex Human S100A4 at this time.