SLC7A10/Asc-1
Code No: BMP056
Background:
SLC7A10, also known as Asc-type amino acid transporter 1 (Asc-1), is a member of the cationic amino acid transporter/glycoprotein-associated family. It functions, in association with the cell surface glycoprotein SLC3A2/4F2hc/CD98, as a sodium-independent high-affinity transporter for small neutral amino acids, particularly, D-serine. The SLC7A10 protein has been observed in various tissues including the brain, kidney, heart, liver, lung, pancreas, placenta, and skeletal muscle. Knockout of the slc7a10 gene in mice causes tremors, ataxia, and seizures that result in early postnatal death.
Product Type:
Primary Antibody
Species Reactivities:
Human
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BMP039 anti-SLC7A1/CAT1 (polyclonal)
BMP040 anti-SLC7A3/CAT3 (polyclonal)
BMP057 anti-SLC7A4/CAT4 (polyclonal)
BMP041 anti-SLC7A8/LAT2 (polyclonal)
BMP021 anti-SLC7A9/B0,+AT (polyclonal)
BMP056 anti-SLC7A10/Asc-1 (polyclonal)
References:
Rutter, A. R., et al., Eur. J. Neurosci. 25, 1757-1766 (2007)
Fukasawa, Y., et al., J. Biol. Chem. 275, 9690-9698 (2000)
Nakauchi, J., et al., Neurosci. Lett. 287, 231-235 (2000)
Formulation:
100 uL volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Reactivity:
This antibody can be used to stain endogenous antigen in paraffin embedded human tissues including the brain by Immunohistochemistry. The reactivity has been confirmed by Immunocytochemistry and intracellular Flow cytometry to detect the full length of human SLC7A10 transiently expressed in HEK 293T cells.
Intended Use:
For Research use only. Not for use in diagnostic procedure.
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