SLC5A11, also known as Na+-myo-inositol symporter 2 (SMIT2), belongs to the sodium/glucose cotransporter family. Although SLC5A11 predominantly transports myo-inositol, it also has weak affinity for glucose. Northern blot analysis has revealed that the highest levels of SLC5A11 expression are found in the heart, skeletal muscles, kidney, liver, and placenta. The SLC5A11 gene has been mapped to chromosome 16 p12-p11. One group of researchers, who aimed to identify an autoimmune modifier gene in the pericentromeric region of chromosome 16, reported that SLC5A11 may be associated with systemic lupus erythematosus.