SLC4A1/AE1 Polyclonal Antibody

Target:

SLC4A1/AE1

Background:

SLC4A1/AE1/Band3/CD233, a member of the anion exchanger family, is the major glycoprotein of the erythrocyte membrane. SLC4A1 has an important role for the high rate exchange of chloride by bicarbonate ion during carbon dioxide transport by erythrocytes. Defective mutations of SLC4A1 gene have been reported to cause either the erythroid disorders including spherocytic hemolytic anaemia or ovalocytosis, or distal renal tubular acidosis. One SLC4A1 null human is also known with very severe anemia and nephrocalcinosis.

Size:

100 μL

Application:

WB

Application:

IHC

Clone Number:

Polyclonal

Product Type:

Primary Antibody

Host Species:

Rabbit

Species Reactivities:

Human

Storage Temp. (°C):

-20

Shipping Temp. (°C):

4

References:

1) Shayakul, C., and Alper, S. L., Clin. Exp. Nephrol. 8, 1-11 (2004)
2) Karet, F. E., et al., PNAS 95, 6337-6342 (1998)
3) Lux, S. E., et al., PNAS 86, 9089-9093 (1989)
4) Palumbo, A. P., et al., Am. J. Hum. Genet. 39, 307-316 (1986)

Formulation:

100 μL volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Reactivity:

This antibody can be used to stain erythrocytes in paraffin embedded human tissues by immunohistochemistry. The reactivity of this antibody has been confirmed by Western blotting to detect the full-length of human SLC4A1 transiently expressed in HEK 293T cells

Intended Use:

For Research use only. Not for use in diagnostic procedure.

Product Catalog

SLC4A1/AE1 Polyclonal Antibody

More like this