Solutions for Life Science & Diagnostics
Anti-CD117 (c-Kit) (Human) pAb
Additional Information
Anti-CD117 (c-Kit) (Human) pAb Specifications
| Background: | c-Kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-Kit ligand to c-Kit, initiates autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol- 3-kinase, src family kinases, and JAK/STAT pathways. The roles of c-Kit include maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-Kit has been proposed to play a functional role, and becomes target molecule for drug development. |
| Clonality: | Polyclonal |
| Formulation: | 1 mg/mL in PBS/50% glycerol, pH7.2 |
| Gene ID Human: | 3815 |
| Gene ID Mouse: | 16590 |
| Host Species: | Rabbit |
| Immunogen: | Carrier protein conjugated synthetic peptide (C-terminal of c-kit gene product （K963）) |
| Regulatory Statement: | For Research Use Only. Not for use in diagnostic procedures. |
| Isotype: | IgG |
| Product Type: | Primary Antibody |
| Shipping: | 4 |
| Size: | 100 µg |
| Species Reactivities: | Human |
| Status: | RUO |
| Storage: | -20℃ |
| Target: | CD117 |
Applications: WB, IC, IH
| IHC: | 1:200 (Heat treatment is necessary for paraffin em |
| WB: | 1:1000 |
There are no references for Anti-CD117 (c-Kit) (Human) pAb at this time.
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