Anti-CD117 (c-Kit) (Human) pAb
Anti-CD117 (c-Kit) (Human) pAb Specifications
|Background:||c-Kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-Kit ligand to c-Kit, initiates autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol- 3-kinase, src family kinases, and JAK/STAT pathways. The roles of c-Kit include maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-Kit has been proposed to play a functional role, and becomes target molecule for drug development.
|Formulation:||1 mg/mL in PBS/50% glycerol, pH7.2|
|Gene ID Human:||3815|
|Gene ID Mouse:||16590|
|Immunogen:||Carrier protein conjugated synthetic peptide (C-terminal of c-kit gene product （K963）)|
|Regulatory Statement:||For Research Use Only. Not for use in diagnostic procedures.|
|Product Type:||Primary Antibody|
Applications: WB, IC, IH
|IHC:||1:200 (Heat treatment is necessary for paraffin em|
There are no references for Anti-CD117 (c-Kit) (Human) pAb at this time.